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Dr. Virginia McDonough-Stukey always knew she wanted to be a biologist, even when she wasn亚洲色吧檛 sure what a biologist did for a living. In college, she majored in biology and found that she really liked bench work. So, after she graduated, she worked as a lab tech for several years. She learned a lot from that time 亚洲色吧� not least that she wanted to go to graduate school to learn more science.

Dr. McDonough-Stukey loved graduate school and was lucky enough to work on a fantastic project on the molecular biology of lipid metabolism with a great mentor, Dr. Charles Martin, and great lab mates (one of whom she eventually married). In grad school, she taught several classes as a teaching assistant, and discovered that teaching undergraduates was very gratifying. Dr. McDonough-Stukey knew she wanted to be able to do the two things she loved 亚洲色吧� teach and do research 亚洲色吧� at a place that valued both. She did a post-doc with another great mentor, Dr. George Carman, shifting emphasis a bit to study the biochemistry of phospholipid metabolism.

When it came time to look for a permanent position, Virginia looked for a place she could continue her work on lipid metabolism, but also work with undergraduates. Her search led her to Hope, where she has been since 1995. She teaches courses with a major emphasis on molecular biology, genetics and cell biology.

AREAS OF Expertise

Dr. McDonough-Stukey亚洲色吧檚 lab investigates how cells sense which lipids have been made available to them in their diet, and, in turn, regulate their gene expression to control lipid synthesis. She and her team work with the model eukaryotic organism, baker亚洲色吧檚 yeast Saccharomyces cerevisiae. She is currently in the process of identifying genes whose products are involved in this sensing, the subsequent signal transduction and gene expression regulation.

EDUCATION

• Post-Doc, biochemistry, 1992亚洲色吧�1995, Rutgers University
• Ph.D., cell and developmental biology, 1992, Rutgers University and the University of Medicine and Dentistry of New Jersey
• B.S., biology, 1983, Rutgers University

Selected Grants, Honors and Awards

• 亚洲色吧淩egulation of the Stearoyl-CoA Desaturase by Dietary Fatty Acids,亚洲色吧� National Institutes of Health grant ($246,972), 2019亚洲色吧�2022
• Den Uyl Summer Research Fellow, Hope College, 2017
• 亚洲色吧淰irus-Bacterial Host Interactions During Infection,亚洲色吧� Jacob E. Nyenhuis faculty-student collaborative research grant, Hope College, 2015
• 亚洲色吧淒iscovery and Functional Investigation of Cytotoxic Phage Genes亚洲色吧� (with J. Stukey), HHMI Faculty Research Award for faculty-student collaborative project, Hope College, 2014

PUBLISHED WORK

• 亚洲色吧淢y Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships亚洲色吧� (with V. Muilenburg et al.), Course Source, forthcoming
• 亚洲色吧淎 Transcriptional Regulatory System of the S. cerevisiae OLE1 Gene Responds to Fatty Acid Species and Intracellular Amount, and Not Simply Membrane Status亚洲色吧� (with M. Willey et al.), Journal of Lipids, 2020
• 亚洲色吧淢ice Lacking ARV1 Have Reduced Signs of Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease亚洲色吧� (with C. Gallo-Ebert et al.), Journal of Biological Chemistry, 2018
• 亚洲色吧淚mproving Journal Club: Increasing Student Discussion and Understanding of Primary Literature in Molecular Biology through the Use of Dialectical Notes,亚洲色吧� Biochemistry and Molecular Biology Education, 2012
• 亚洲色吧淎 Role for MGA2, But Not SPT23, in Activation of Transcription of ERG1 in Saccharomyces cerevisiae,亚洲色吧� Biochemical and Biophysical Research Communications, 2010
• 亚洲色吧淓xpression of the S. cerevisiae PIS1 Gene is Modulated by Multiple ATGs in the Promoter,亚洲色吧� Biochemical and Biophysical Research Communications, 2006
• 亚洲色吧淕rowth Temperature Affects Accumulation of Exogenous Fatty Acids and Fatty Acid Composition in Schizosaccharomyces pombe,亚洲色吧� Antonie van Leeuwenhoek, 2004
• 亚洲色吧淢utations in erg4 Affect the Sensitivity of Saccharomyces cerevisiae to Medium Chain Fatty Acids,亚洲色吧� Biochimica et Biophysica Acta, 2002

View all of Dr. Virginia McDonough-Stukey亚洲色吧檚 published work in .